• Kohei Otake, Shogo Misu, Akio Yamamoto, Takumi Yamaguchi, Chisato Nagatani, Hideki Sakai, Masahiro Kaneko, Akira Ishikawa, and Hiromi Tomioka.
• Department of Physical Therapy, Faculty of Nursing and Rehabilitation, Chubu Gakuin University, Seki City, Japan; Department of Rehabilitation, Kobe City Medical Center West Hospital, Kobe City, Japan; and Department of Public Health, Kobe University Graduate School of Health Sciences, Kobe City, Japan. otake-kohei@st.chubu-gu.ac.jp.
• Respir Care. 2024 Sep 10.

BackgroundDyspnea and desaturation during exercise are essential assessment items for pulmonary rehabilitation. Characterizing patients using these 2 factors may be important for providing more effective pulmonary rehabilitation. This study aimed to categorize subjects with interstitial lung disease (ILD) using dyspnea and desaturation at the end of the 6-min walk test (6MWT).MethodsThis was a retrospective study including 230 stable subjects with ILD who underwent 6MWT in our out-patient department at a general hospital in Japan. The modified Borg scale and oxygen saturation determined by SpO2 at the end of the 6MWT were used for cluster analysis using the k-means method with k = 4.ResultsSubjects were classified into 4 characteristic clusters. SpO2 at the end of the 6MWT was lower in cluster 4 (80.5 ± 3.0%) than in clusters 1 (94.3 ± 2.0%), 2 (94.3 ± 1.9%), and 3 (87.9 ± 1.8%) and was lower in cluster 3 than in clusters 1 and 2. The modified Borg scale score at the end of the 6MWT was higher in clusters 2 (4 [3-8]), 3 (3 [0-9]), and 4 (4 [0-7]) than in cluster 1 (0.5 [0-2.0]) and was higher in cluster 2 than in cluster 3.ConclusionsSubjects with ILD were classified into 4 characteristic clusters using dyspnea and SpO2 at the end of the 6MWT. The 4 clusters are characterized as follows: Cluster 1 had mild desaturation and mild dyspnea; cluster 2 had mild desaturation and severe dyspnea; cluster 3 had both moderate desaturation and dyspnea, and cluster 4 had both severe desaturation and dyspnea. These classification data offer insight for individualized pulmonary rehabilitation for patients with ILD.Copyright © 2024 by Daedalus Enterprises.

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