• Transl Res · Feb 2025

    Breaking New Ground: Unraveling the USP1/ID3/E12/P21 Axis in Vascular Calcification.

    • Aoran Huang, Jianyun Rao, Xin Feng, Xingru Li, Tianhua Xu, and Li Yao.
    • Department of Nephrology, The First Hospital of China Medical University, Shenyang 110000, PR China.
    • Transl Res. 2025 Feb 1; 276: 1201-20.

    AbstractVascular calcification (VC) poses significant challenges in cardiovascular health. This study employs single-cell transcriptome sequencing to dissect cellular dynamics in this process. We identify distinct cell subgroups, notably in vascular smooth muscle cells (VSMCs), and observe differences between calcified atherosclerotic cores and adjacent regions. Further exploration reveals ID3 as a key gene regulating VSMC function. In vitro experiments demonstrate ID3's interaction with USP1 and E12, modulating cell proliferation and osteogenic differentiation. Animal models confirm the critical role of the USP1/ID3/E12/P21 axis in VC. This study sheds light on a novel regulatory mechanism, offering potential therapeutic targets.Copyright © 2024 Elsevier Inc. All rights reserved.

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