• Magdi M Salih, Dooaa A Abdulgafor, Haytham A Dahlawi, and Eman H Khalifa.
• From the Department of Clinical Laboratory Sciences (Salih, Dahlawi), College of Applied Medical Sciences, Taif University, Taif, from the Department of Medical Laboratory (Abdulgafor), King Faisal Special Hospital Research Center, Al-Madinah Al-Munawarah, and from the Department of Laboratory Medicine (Khalifa), Faculty of Applied Medical Science, University of Al Baha, Al Baha, Kingdom of Saudi Arabia.
• Saudi Med J. 2024 Oct 1; 45 (10): 102810331028-1033.

ObjectivesTo assess argyrophilic nucleolar organizer regions (AgNORs) in 60 patients with primary breast carcinoma and evaluated their association with clinical prognostic parameters of breast cancer.MethodsArgyrophilic nucleolar organizer regions were stained in paraffin sections of the tissues using Ploton's silver method. For each sample, the number of AgNORs within the nuclei of 100 tumor cells was counted. The average number of AgNORs per nucleus was calculated, and the results were expressed as mean.ResultsThe number of AgNORs was significantly higher in breast invasive ductal carcinoma (6.6) compared to benign breast tumors (fewer than 2.0). However, differences in AgNOR counts across different age groups were not statistically significant.ConclusionThis study suggests that AgNOR counts could be used as a potential procedure for estimating proliferation characteristics in histopathological sections of benign and malignant breast lesions. Argyrophilic nucleolar organizer region counts may also be valuable for identifying high-risk patients and indicating tumor aggressiveness. A larger study with an increased sample size that incorporates both AgNOR numbers and Ki67 scores for assessing cell kinetics is needed to confirm our findings.Copyright: © Saudi Medical Journal.

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