• Wenzhong Li and Liping Tang.
• Department of Neurosurgery, Tianshui Hospital of Traditional Chinese and Western Medicine, Gansu, China.
• Medicine (Baltimore). 2024 Oct 18; 103 (42): e39955e39955.

BackgroundGreater occipital nerve (GON) block may help relieve acute migraine, and this meta-analysis aimed to investigate the influence of GON block on pain relief of acute migraine.MethodsWe systematically searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases, and included randomized controlled trials (RCTs) assessing the efficacy of GON block for acute migraine. Meta-analysis was performed using the random-effect model regardless of the heterogeneity.ResultsFour RCTs and 224 patients were included in the meta-analysis. Compared with control intervention in acute migraine, GON block intervention could significantly reduce pain scores at 45 to 60 minutes (MD = -2.31; 95% CI = -3.08 to -1.53; P < .00001) and pain scores at 30 minutes (MD = -1.95; 95% CI = -2.61 to -1.29; P < .00001), but demonstrated no impact on pain scores at 0 to 15 minutes (MD = -0.46; 95% CI = -1.00 to 0.08; P = .09), sustained headache relief (OR = 1.46; 95% CI = 0.06-36.66; P = .82) or rescue medication (OR = 0.32; 95% CI = 0.01-19.16; P = .59).ConclusionsGON block intervention may be able to alleviate pain intensity for acute migraine patients.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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