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- Yuanyuan Fu, Chongbin Zhong, Junhe Cui, Shengjie Xie, and Chuang Guo.
- Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang, China.
- Arch Med Sci. 2024 Jan 1; 20 (4): 134913571349-1357.
IntroductionTrace mineral micronutrients are essential for periodontal health, and unbalanced levels of trace minerals are related to chronic periodontitis, including copper. We attempted to explore the relationship between cuproptosis and periodontitis.MethodsBulk RNA-seq and single-cell RNA sequencing data were used to analyze expression of cuproptosis-related genes (CRGs) in periodontitis. A mouse periodontitis model was established to verify the expression of key genes.ResultsCuproptosis-related genes were differentially expressed in periodontitis. RT-PCR results confirmed the alteration of five key genes in the mouse model.ConclusionsCuproptosis is an important player in the pathophysiological process of periodontitis.Copyright: © 2024 Termedia & Banach.
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