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- Malgorzata Baranska, Mariola Rychlik-Sych, Michal Dudarewicz, Anna Wiktorowska-Owczarek, and Jacek Owczarek.
- Department of Hospital Pharmacy, Laboratory of Pharmacogenetics, Medical University of Lodz, Poland.
- Arch Med Sci. 2024 Jan 1; 20 (4): 132813331328-1333.
IntroductionThe present study concerns a connection of the Q192RPON1 polymorphism with atherosclerosis requiring percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) in the Polish population.MethodsA total of 282 individuals who underwent coronary angiography took part in this study. The polymorphism was determined with the PCR-RFLP method.ResultsThe odds ratio for atherosclerosis in carriers of the 192RR genotype was 2.50 (p = 0.002). The median HDL-C concentration was significantly lower in the study group than the control group (p = 0.02).ConclusionsThe presence of the 192RR genotype and 192R allele are indicative of at least a two-fold increased risk of atherosclerosis requiring PCI or CABG in the Polish population.Copyright: © 2024 Termedia & Banach.
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