• Aarti Belgamwar, Rarchita Sharma, Yogesh Mali, Yogeeta O Agrawal, and Kartik T Nakhate.
• Department of Pharmaceutics, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule, Maharashtra 424001, India.
• Neuroscience. 2024 Dec 6; 562: 9010590-105.

AbstractA stroke, also known as cerebrovascular accident, is a medical emergency that occurs when the blood supply to the brain is interrupted. This disruption can happen in two main ways: through a hemorrhagic stroke, where a blood vessel in the brain bursts, or through an ischemic stroke, where a blood clot blocks an artery. Both types of stroke cause damage to brain cells, leading to a range of health complications. Globally, stroke ranks as the second leading cause of death and disability.This review provides an overview of stroke, focusing on its early detection, current treatment options, and emerging therapies. We discuss the complex mechanisms that contribute to stroke development, including the roles of cells, biomolecules, and blood vessels. Additionally, the review explores recent advances in the use of nanoparticles to enhance the efficacy of the pharmacotherapy of stroke, particularly ischemic stroke. Ongoing clinical trials in stroke management are also highlighted. Timely diagnosis and prompt intervention are critical for improving patient outcomes.We aim to increase awareness and understanding of stroke among researchers and healthcare professionals, ultimately improving patient care.Copyright © 2024 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights reserved.

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