• Bo Wang, Yuan Si, Yan Dou, Yongcai Li, Zhongxin Liu, Chaokang Huang, and Xin Xu.
• Department of Pathology, Xingtai People's Hospital, Hebei Medical University Affiliated Hospital, Xingtai, Hebei, P.R. China.
• Medicine (Baltimore). 2024 Oct 4; 103 (40): e39851e39851.

RationaleGastric large cell neuroendocrine carcinoma (LCNEC) is a rare, aggressive neuroendocrine carcinoma that arises from the stomach and with high malignancy. Patients with gastric LCNEC usually have a poor prognosis. The standard treatment plan has not been established and its curative effect is poor. The present study described 2 cases diagnosed with gastric LCNEC and reviewed in depth the literature to improve our understanding more about this uncommon tumor and further to provide more experience to diagnose and treat this disease.Patient ConcernsThe present study reported 2 cases of gastric LCNEC in male patients aged 51 and 73 years old, respectively. Both patients had epigastric discomfort, pain, acid reflux and heartburn. The medical history was unremarkable.DiagnosesThe ulcerative lesion located at gastric was examined in the 2 patients by taking the esophagogastroduodenoscopy (EGO), computed tomography (CT) and digital gastrointestinal radiography (GI), that both were suspected gastric malignancy. Endoscopic biopsies of the tumor led to the initial diagnosis of gastric cancer. Postoperative pathological and immunohistochemical examinations of the surgical specimens confirmed that 1 case had mixed adeno-neuroendocrine carcinoma (MANEC) and the other had LCNEC.InterventionsBoth patients underwent surgical resection and received etoposide-cisplatin combination chemotherapy following surgery.OutcomesThe operation was successful. Both patients had uneventful recoveries following surgery, and had been followed-up regularly. The general condition was satisfactory, and no tumor metastasis was observed at present.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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