• Yong-Liang Zhou, Shi-Min Liu, Wen-Feng Cao, Xian-Min Cao, Ling-Feng Wu, and An Wen.
• Department of Neurology, Jiangxi Provincial People's Hospital (The First Affiliated Hospital of Nanchang Medical College), Nanchang, People's Republic of China.
• Medicine (Baltimore). 2024 Oct 4; 103 (40): e40032e40032.

RationaleCerebral infarction is a common ischemic cerebrovascular disease, associated with high rates of morbidity, disability, and recurrence, that can seriously affect patient physical and mental health, as well as quality of life. Carotid artery stenosis is an independent risk factor of cerebral infarction. Following rapid developments in interventional technology and materials science, carotid artery stenting has arisen an important treatment option for carotid artery stenosis. However, surgery is associated with complications, such as postoperative hyperperfusion syndrome, which poses a serious threat to the life and health of patients. Staged angioplasty (SAP), that is, one-time revascularization of the carotid artery stenting, is divided into 2 stages. This method reduces the occurrence of hyperperfusion syndrome after stenting by increasing the ipsilateral cerebral blood flow in stages and gradually increasing the cerebral perfusion pressure.Patient ConcernsHerein, we present 2 cases of elderly patients with severe carotid artery stenosis who underwent SAP to prevent hyperperfusion syndrome.DiagnosesThe final diagnosis was based on cervical vascular color Doppler ultrasonography, cervical vascular magnetic resonance angiography, and cerebral vascular digital subtraction angiography.InterventionBoth patients with severe carotid artery stenosis underwent a staged intravascular intervention.OutcomesBoth patients were followed up for 1 year, with neither developing any new cerebral infarction or recurrent stent restenosis.LessonsWhen treating SAP, it is crucial to consider that patients with unstable carotid plaques may not be suitable for staging. Additionally, during phase II carotid stenting, it is important to assess any changes in the arterial morphology and select the appropriate device accordingly.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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