• Kai-Yong Huang, Zhen-Zhen Yu, Jia-Jun Tu, Xian-Yan Tang, Jin-Meng Huang, Tian-Ming Lu, Yu-Qian Lu, Mei-Chun Huang, Jing Zhou, Andrea B Maier, Kaisy Xinhong Ye, Zi Yang, Lei Feng, and Guo-Dong Lu.
• Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
• Medicine (Baltimore). 2024 Oct 4; 103 (40): e39943e39943.

AbstractThis study aimed to examine the association between constipation and mild cognitive impairment (MCI); and further elucidate the possible mechanisms involved. A cross-sectional study was conducted among community-dwelling elders (N = 789) in Nanning, China. Trained research staffs collected detailed information through questionnaires and physical examinations. A Bayesian network model was used to explore the hypothesized causal path. Synergistic effects of constipation with infrequent fruit consumption, inactive physical exercise, or history of stroke were observed in the risks of MCI occurrence. The Bayesian network model analyses showed 3 hypothesized causal-association paths leading to MCI occurrence. Among these, constipation, history of stroke, and years of schooling were directly related to the occurrence of MCI. Years of schooling indirectly affected MCI through infrequent fruit consumption and constipation; or through inactive physical exercises and history of stroke. This study demonstrates a direct association between constipation and increased risks of MCI.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

23 keywords...

hide…