• Yu-Xiang Zhang, Yang Li, Yong Wang, You-Feng Ren, Yue Yang, Jing Qi, Hui Yang, Xuan Liang, and Rong-Fang Zhang.
• Department of Allergy, Gansu Maternal and Child Health Hospital, First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, China.
• Medicine (Baltimore). 2024 Oct 11; 103 (41): e39665e39665.

BackgroundMycoplasma pneumoniae is a significant cause of respiratory infections in children, often leading to severe pneumonia. This study aimed to assess the clinical relevance of interferon-gamma (interferon-γ), D-dimer, lactate dehydrogenase (LDH), and C-reactive protein (CRP) as biomarkers in the severity of mycoplasma pneumonia in pediatric patients.MethodsIn this prospective study, 203 pediatric patients with mycoplasma pneumonia were classified into mild (123 patients) and severe (80 patients) groups. Biomarkers including interferon-γ, D-dimer, LDH, and CRP were measured and analyzed. Statistical methods employed included Pearson and Spearman correlation analyses, logistic regression, and receiver operating characteristic curve analysis.ResultsThe severe group exhibited significantly higher median and interquartile ranges for interferon-γ, D-dimer, LDH, and CRP compared to the mild group. Logistic regression identified IL-10, IL-6, interferon-γ, tumor necrosis factor-alpha, D-dimer, and LDH as independent predictors of severity, with the model achieving 92% accuracy. Receiver operating characteristic curve analysis showed optimal diagnostic efficacy for interferon-γ, D-dimer, and LDH, with the best threshold values being 8.11, 0.64, and 379, respectively. A significant positive correlation was observed between IL-6 and LDH, as well as between interferon-γ and D-dimer.ConclusionThis study showed that interferon-γ >8.11, D-dimer >0.64, and LDH >379 have an important role in the assessment of severe mycoplasma pneumonia.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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