• Medicine · Oct 2024

    Review

    Effect of glucagon-like peptide-1 receptor agonists on prostate cancer: A review.

    • Xu Yu and Jie Liu.
    • Linyi People's Hospital of Shandong Second Medical University, Weifang, Shandong, China.
    • Medicine (Baltimore). 2024 Oct 11; 103 (41): e39956e39956.

    AbstractGlucagon-like peptide-1 receptor agonist (GLP-1RA) is widely used in the treatment of type 2 diabetes mellitus (T2DM) for its significant hypoglycemic effect, weight loss and small side effects. Some studies have shown that GLP-1RA has an inhibitory effect on prostate cancer, and its application will produce adverse effects associated with an increased or decreased risk of some tumors. GLP-1R is widely expressed by various types of cells and tissues in the human body, so GLP-1RA has attracted wide clinical attention to the occurrence, development and prognosis of tumors, which brings more new directions and hopes for the treatment of prostate cancer. This paper describes the expression of glucagon-like peptide-1 receptor (GLP-1R) in prostate cancer and the effects of glucagon-like peptide-1 receptor agonist (GLP-1RA) on prostate cancer.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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