• Lingyu Ma, Rui Ma, Ran Ran, Jiaying Li, Xuefeng Pan, Zhiheng Guo, Xichen Lin, Dezhong Wen, Shuyao Wu, and Ying Chen.
• Department of Gynecology and Obstetrics Center, the First Hospital of Jilin University, Jilin, China.
• Medicine (Baltimore). 2024 Oct 11; 103 (41): e39778e39778.

AbstractPreeclampsia is a complex disorder with genetic and environmental interactions. In this study, we analyzed the associations of KCNQ1gene polymorphisms with preeclampsia in Chinese pregnant women. The 3 candidate single-nucleotide polymorphisms rs231840, rs2237892, and rs2237895 were genotyped in this case-control study; clinical and biochemical data were included and SNPs were gathered from 248 individuals with preeclampsia and 237 controls. The TT genotype rs231840 increased the risk of preeclampsia (OR: 1.633; 95% CI: 1.027-2.597) and was associated with higher blood glucose levels. The haplotype TCA containing the allele of rs231840 (T), rs2237892 (C), and rs2237895 (A) was highly protective against preeclampsia and associated with the levels of blood glucose in preeclamptic patients. A novel function was found for the haplotype CCA in SNPs rs231840 (C), rs2237892 (C), and rs2237895 (A); it might be a protective combination against preeclampsia. The KCNQ1 (TT) genotype seems to be associated with preeclampsia and might affect the regulation of blood glucose in Chinese pregnant women.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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