• Yuqiu Lu, Tianmei Zhou, Yueqian Shen, and Manxing Zhou.
• The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
• Medicine (Baltimore). 2024 Oct 11; 103 (41): e40011e40011.

AbstractPrevious studies have shown a significant association between the triglyceride glucose index (TyG) and suicidal ideation in Korean women. However, this association has not yet been examined among American adults. This study aims to investigate the association between TyG and suicidal ideation using data from the National Health and Nutrition Examination Survey. The National Health and Nutrition Examination Survey database from 2005 to 2018 was used, including samples ≥20 years old. Suicidal ideation was assessed through questionnaires, and the TyG was derived from fasting triglyceride and glucose measurements. Weighted logistic regression models were used to analyze the relationship between the TyG and suicidal ideation. Generalized additive model curves explored the nonlinear relationship, while stratified and sensitivity analyses assessed potential interactions and the robustness of the findings. A significance level of P < .05 was considered statistically significant. A total of 15,694 participants were enrolled, of whom 3.67% participants showed suicidal ideation. The mean TyG index for participants with or without suicidal ideation was 8.82 ± 0.76, 8.65 ± 0.68, respectively (P < .001). Multivariable logistic regression showed that a higher level of TyG were associated with a higher likelihood of suicidal ideation (OR = 1.20; 95% CI, 1.05-1.38) after full adjustment. Subgroup analysis and interaction tests showed no significant correlation between gender, age, race, marital status, education, body mass index, poverty income ratio, smoking status, drinking status, diabetes, hypertension, stroke, and cancer (P > .05 for all interactions). Our findings confirm a significant and positive association between the TyG and suicidal ideation among American adults. Further large-scale prospective studies are needed to analyze the role of TyG in suicidal ideation.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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