• Huiqing Zhang, Jie Lin, Hanqi Lu, Yunliang Zhong, Lie Deng, Bin Kuang, and Qiang Li.
• Guangzhou University of Chinese Medicine, Dongguan Hospital of Traditional Chinese Medicine, Dongguan, Guangdong 523000, China.
• Medicine (Baltimore). 2024 Oct 25; 103 (43): e39809e39809.

RationalePodocyte infolding glomerulopathy (PIG) is a rare glomerular disease, its diagnosis mainly depends on pathological manifestations of the kidney. Few clinical cases of PIG have been reported, but it is sometimes associated with connective tissue diseases. Here we describe a case of systemic lupus erythematosus (SLE) with PIG and undertake a review of the literature.Patient ConcernsA 34-year-old female patient was admitted to our hospital in August 2019 with repeated facial erythema and proteinuria for more than 10 years. The patient was previously diagnosed with SLE.DiagnosisSystemic lupus erythematosus.InterventionsRenal biopsy was performed to investigate ongoing proteinuria and the results were consistent with PIG. Treatment with methylprednisolone, hydroxychloroquine sulfate, mycophenolate mofetil, and candesartan ester.OutcomesImproved the patient's condition and resolved the proteinuria.LessonsThis study reported a case of PIG and SLE. The patient was diagnosed according to biopsy, and the disease remain stable after immunosuppressive therapy. It is recommended to carefully study renal biopsies from patients with proteinuria and underlying autoimmune diseases to identify additional cases.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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