• Yasemin Ozkan, Mahmut Alpayci, and Veysel Delen.
• Department of Physical Medicine and Rehabilitation, Adnan Menderes University, Aydin, Turkiye.
• J Coll Physicians Surg Pak. 2024 Nov 1; 34 (11): 129913021299-1302.

ObjectiveTo assess the relationship between vitamin D and haematological inflammatory indices (HII) in chronic low back pain (CLBP) patients.Study DesignDescriptive study. Place and Duration of the Study: Harran University Hospital, Sanliurfa, Turkiye, between September 2023 and February 2024.MethodologyA total of 100 CLBP patients were divided into three groups according to their vitamin D levels as deficiency (<20 µg/L), insufficiency (20-30 µg/L), and sufficiency (30-80 µg/L). Demographic characteristics, serum parameters, and HII were compared among the three groups. Additionally, the association between vitamin D and other parameters were investigated.ResultsThe three groups were similar in terms of age (p = 0.640), gender distribution (p = 0.057), body mass index (BMI, p = 0.855), C-reactive protein (CRP, p = 0.965), leucocyte count (p = 0.979), neutrophil count (p = 0.525), lymphocyte count (p = 0.246), monocyte count (p = 0.485), platelet count (p = 0.878), and HII including neutrophil-to-lymphocyte ratio (NLR, p = 0.335), monocyte-to- lymphocyte ratio (MLR, p = 0.227), platelet-to-lymphocyte ratio (PLR) (p = 0.898), neutrophil-to-lymphocyte*platelet ratio (NLPR, p = 0.543), systemic inflammatory index (SII, p = 0.300), systemic inflammatory response index (SIRI, p = 0.187), and aggregate index of systemic inflammation (AISI, p = 0.219). No significant correlation was found between vitamin D concentration and other parameters (p >0.05).ConclusionThe coexistence of vitamin D deficiency and increased HII may accompany inflammatory conditions. However, no significant association was found between vitamin D level and HII in non-inflammatory CLBP.Key WordsInflammation, Low back pain, Neutrophil, Complete blood count, Vitamin D.

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