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Chinese medical journal · Nov 2024
Engineering and targeting potential of CAR NK cells in colorectal cancer.
- Muhammad Babar Khawar, Ali Afzal, Shuangshuang Dong, Yue Si, and Haibo Sun.
- Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225009, China.
- Chin. Med. J. 2024 Nov 5.
AbstractColorectal cancer (CRC), a major global health concern, necessitates innovative treatments. Chimeric antigen receptor (CAR) T cells have shown promise, yet they grapple with challenges. The spotlight pivots to the rising heroes: CAR natural killer (NK) cells, offering advantages such as higher safety profiles, cost-effectiveness, and efficacy against solid tumors. Nevertheless, the specific mechanisms underlying CAR NK cell trafficking and their interplay within the complex tumor microenvironment require further in-depth exploration. Herein, we provide insights into the design and engineering of CAR NK cells, antigen targets in CRC, and success in overcoming resistance mechanisms with an emphasis on the potential for clinical trials.Copyright © 2024 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.
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