• Xinyue-ChengDepartment of Radiology, the First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: chengxy22@mails.jlu.edu.cn., Wenjing-GuDepartment of Otorlaryngology, the First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: guwejing@jlu.edu.cn., Xuewei-LiDepartment of Radiology, the First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: lixw21@mails.jlu.edu.cn., Yuchen Liang, Dehong-LiuDepartment of Radiology, the First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: liudh23@mails.jlu.edu.cn., and Hongwei-ZhouDepartment of Radiology, the First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: hwzhou@jlu.edu.cn..
• Department of Radiology, the First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: chengxy22@mails.jlu.edu.cn.
• Neuroscience. 2025 Jan 9; 564: 160170160-170.

AbstractPost-stroke basal ganglia aphasia is an unusual and transient form of aphasia resulting from basal ganglia damage. It is commonly believed that the generation of language function primarily resides in regular language regions of the brain; however, recent findings indicate a prevalence of basal ganglia stroke aphasia as high as 22%. Subcortical structures (e.g., basal ganglia) also play an important role in language processing. Aphasia seriously affects the quality of life and functional outcomes of patients, and early diagnosis and intervention are important for the prognosis of and rehabilitation from aphasia after basal ganglia stroke. In recent years, the main diagnostic methods for basal ganglia aphasia include diffusion tensor imaging, diffusion spectral imaging, and functional magnetic resonance imaging, which explore the changes in patients with basal ganglia aphasia compared to those without from the perspectives of fiber tract imaging and brain function alteration, respectively, and are able to predict the recovery of patients before and after treatment. Treatment for post-stroke basal ganglia aphasia includes transcranial magnetic stimulation, a recent emerging therapeutic technique, in addition to conventional medications and speech rehabilitation. Consequently, understanding this condition is crucial. This review delves into its causes, imaging methods, and therapeutic interventions, offering a systematic and comprehensive analysis of these aspects.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

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