• Begoña de Cuevillas, Jose I Riezu-Boj, Fermín I Milagro, Sergio Galera Alquegui, Nancy Babio, Belén Pastor-Villaescusa, Mercedes Gil-Campos, Rosaura Leis, Pilar De Miguel-Etayo, Luis A Moreno, Jordi Salas-Salvadó, J Alfredo Martínez, and Santiago Navas-Carretero.
• Department of Nutrition, Food Sciences and Physiology, Center for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
• Nutrition. 2024 Oct 18; 130: 112603112603.

ObjectivesChildhood obesity continues to rise worldwide. Family gut microorganisms may be associated with childhood obesity. The aim of the study was to analyze bacterial similarities in fecal microbiota composition between parent-offspring pairs as linked to body weight.MethodsA total of 146 father/mother and offspring pairs were categorized into four groups according to the weight status of the parent-child pair as follows: group 1, parent and child with normal weight; group 2, parent and child with overweight/obesity; group 3, parent with normal weight and child with overweight/obesity; group 4, parent with overweight/obesity and child with normal weight. Anthropometric measurements and lifestyle assessments were performed in all participants. Microbiota characteristics were determined by 16S ribosomal RNA gene sequencing. Logistic regression models were performed to determine whether the abundance of any bacteria was able to predict childhood obesity. Moreover, receiver operating characteristic curves were fitted to define the relative diagnostic strength of bacterial taxa for the correct identification of childhood obesity.ResultsThe absence/abundance of Catenibacterium mitsuokai, Prevotella stercorea, Desulfovibrio piger, Massiliprevotella massiliensis, and Phascolarctobacterium succinatutens was involved in body weight family associations. A positive relationship between P. succinatutens richness from parents and M. massiliensis from children was observed with regard to body weight status (odds ratio, 1.14, P = 0.013).ConclusionsThis study describes five potential gut bacteria that may be putatively involved in family weight status relationships and appear to be useful for predicting obesity.Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

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