• Alina Bergholz, Linda Grüßer, Wiam T A K Khader, Pawel Sierzputowski, Linda Krause, Marc Hein, Julia Wallqvist, Sebastian Ziemann, Kristen K Thomsen, Moritz Flick, Philipp Breitfeld, Moritz Waldmann, Ana Kowark, Mark Coburn, Karim Kouz, and Bernd Saugel.
• Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
• J Clin Anesth. 2025 Jan 1; 100: 111687111687.

Study ObjectiveWe hypothesize that personalized perioperative blood pressure management maintaining intraoperative mean arterial pressure (MAP) above the preoperative mean nighttime MAP reduces perfusion-related organ injury compared to maintaining intraoperative MAP above 65 mmHg in patients having major non-cardiac surgery. Before testing this hypothesis in a large-scale trial, we performed this bicentric pilot trial to determine a) if performing preoperative automated nighttime blood pressure monitoring to calculate personalized intraoperative MAP targets is feasible; b) in what proportion of patients the preoperative mean nighttime MAP clinically meaningfully differs from a MAP of 65 mmHg; and c) if maintaining intraoperative MAP above the preoperative mean nighttime MAP is feasible in patients having major non-cardiac surgery.DesignBicentric pilot randomized trial.SettingUniversity Medical Center Hamburg-Eppendorf, Hamburg, Germany, and RWTH Aachen University Hospital, Aachen, Germany.PatientsPatients ≥ 45 years old having major non-cardiac surgery.InterventionsPersonalized blood pressure management.MeasurementsProportion of patients in whom preoperative automated nighttime blood pressure monitoring was possible; proportion of patients in whom the preoperative mean nighttime MAP clinically meaningfully differed from a MAP of 65 mmHg (difference > ±10 mmHg); intraoperative time-weighted average MAP below the preoperative mean nighttime MAP.Main ResultsWe enrolled 105 patients and randomized 98 patients. In 98 patients (93 %), preoperative automated nighttime blood pressure monitoring was possible. In 83 patients (85 %), the preoperative mean nighttime MAP clinically meaningfully differed from a MAP of 65 mmHg. The median time-weighted average MAP below the preoperative mean nighttime MAP was 3.29 (1.64, 6.82) mmHg in patients assigned to personalized blood pressure management.ConclusionsIt seems feasible to determine the effect of personalized perioperative blood pressure management maintaining intraoperative MAP above the preoperative mean nighttime MAP on postoperative complications in a large multicenter trial.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

30 keywords...

hide…