• Lingli Guo, Fanghua Wu, and Jiaojiao Yang.
• Lingli Guo, Department of Psychosomatic Disorders, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, Huzhou, Zhejiang Province 313000, P.R. China.
• Pak J Med Sci. 2024 Dec 1; 40 (11): 273937452739-3745.

ObjectiveThe objective of the current review aimed to assess if patients with bipolar disorder (BD) have an increased risk of stroke.MethodsA literature search was conducted on PubMed, Embase, ScienceDirect, and Web of Science for studies published from inception to 20th June 2023 and reporting the association between BD and stroke.ResultsEight studies with 9187894 participants were eligible. Meta-analysis of all eight studies demonstrated that BD patients have an increased risk of stroke as compared to non-BD individuals (HR: 1.60 95% CI: 1.24, 2.05 I2=94%). Results did not change in significance on sensitivity analysis. However, results varied on subgroup analysis based on study location, study type, sample size, and follow-up duration. The effect magnitude was unchanged based on the adjustment of diabetes and hypertension and study quality.ConclusionPatients with bipolar disorder (BD) may have an increased risk of stroke in comparison to the general population. The results are limited by the retrospective nature of the data and high inter-study heterogeneity which demand caution in the interpretation of the outcomes. Protocol Registration: PROSPERO (CRD42023434365), https://www.crd.york.ac.uk/prospero/.Copyright: © Pakistan Journal of Medical Sciences.

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