• Sawsan Mohammed Alblewi.
• Sawsan Mohammed Alblewi Pediatrics Department, Faculty of Medicine, University of Tabuk, Saudi Arabia, PO Box 3378 Tabuk 51941, Saudi Arabia.
• Pak J Med Sci. 2024 Dec 1; 40 (11): 273227382732-2738.

ObjectiveThis meta-analysis aimed to investigate daily versus intermittent iron supplementation among children.MethodsThe author searched the Cochrane Library, PubMed, Medline, and Google Scholar for randomized controlled trials and compared daily versus intermittent iron supplementation. The keywords iron deficiency anemia, iron therapy, daily, twice per week, and once weekly were used. The search was limited to the period January 2012 up to November 2023. The age of participant range from two months to 18 years.ResultOut of the 735 studies, 540 were eligible after removal of duplication, of them, 28 full texts were screened and only 10 studies were included. Daily iron supplementation was better in improving hemoglobin odd ratio, 0.41, 95 CI, 0.38-0.44, Z=26.53, and p-Value <0.001 than intermittent prescription odd ratio, 0.69, 95 CI, 0.67-0.72, Z=49.98, and P-value < 0.001.ConclusionDaily supplementation increased hemoglobin more compared to weekly or twice/week among children with iron deficiency anemia. Further larger studies assessing tolerance and compliance are needed.Copyright: © Pakistan Journal of Medical Sciences.

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