• Mayo Clinic proceedings · Dec 2024

    Review

    Post-Pulmonary Embolism Syndrome-A Diagnostic Dilemma and Challenging Management.

    • Kajal P Shah, Christopher Lee, Robert D McBane, Gregory Piazza, Robert P Frantz, Damon E Houghton, Ana I Casanegra, and Stanislav Henkin.
    • Section of Cardiovascular Medicine, Heart and Vascular Center, Dartmouth Hitchcock Medical Center, Lebanon, NH.
    • Mayo Clin. Proc. 2024 Dec 1; 99 (12): 196519821965-1982.

    AbstractHistorically, research on pulmonary embolism (PE) management has focused on short-term outcomes, such as acute cardiovascular collapse, change in right ventricular function, and in-hospital mortality. However, long-standing functional impairments from acute PE occur in up to half of all patients. This chronic syndrome has been termed the post-PE syndrome, which describes patients who have persistent or worsening symptoms, functional limitations, and cardiorespiratory impairment not explained by a comorbid condition. Diagnosis and management are challenging, and post-PE syndrome remains an underrecognized and undertreated condition. This review seeks to increase awareness of the syndrome that affects a significant portion of PE survivors. The epidemiology, pathophysiology, and clinical features are discussed, followed by a description of imaging findings and management options across the entire spectrum of post-PE syndrome.Copyright © 2024 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

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