• Valentina De Cosmi, Sonia Cipriani, Marie-Louise Syren, Stefano Turolo, Fabio Parazzini, Marco Reschini, Martina Abodi, Walter Vegetti, Francesca Chiaffarino, Camilla Bertoni, Edgardo Somigliana, and Carlo Agostoni.
• Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy; Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, Università degli Studi di Milano, Milan, Italy.
• Nutrition. 2025 Feb 1; 130: 112616112616.

ObjectivesThe present study investigated the relationship between fatty acid levels in whole blood in women undergoing in vitro fertilization and four successive assisted reproductive technology (ART) outcomes.MethodsA cross-sectional study was performed on data from a prospective cohort study conducted between 2014 and 2016.ResultsParticipants were 238 women undergoing in vitro fertilization and participating in a study on the role of lifestyle habits and diet in ART outcomes. Blood polyunsaturated fatty acids were measured by gas chromatography. Overall, higher blood levels of monounsaturated fatty acids and oleic acid and higher ω-6/ω-3 ratio and arachidonic/docosahexaenoic acid ratio were associated with more favorable ART outcomes. By contrast, higher concentrations of long chain polyunsaturated fatty acids tended to be negatively associated with the considered outcomes.ConclusionsFurther prospective studies are needed to determine the ranges of fatty acid concentrations that are optimal for women with subfertility.Copyright © 2024 Elsevier Inc. All rights reserved.

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