• Andrea P Rossi, Luca Scalfi, Pasquale Abete, Giuseppe Bellelli, Mario Bo, Antonio Cherubini, Francesco Corica, BariMauro DiMDResearch Unit of Medicine of Aging, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Geriatric Intensive Care Unit, Department of Geriatrics and Medicine, Azienda Ospedaliero-Universitaria Careggi, F, Marcello Maggio, Maria Rosaria Rizzo, Lara Bianchi, Stefano Volpato, Francesco Landi, and GLISTEN Group Investigators.
• Division of Geriatrics, Department of Medicine, Healthy Aging Center Treviso, Ospedale Cà Foncello, Treviso, Italy. Electronic address: andrea.rossi@aulss2.veneto.it.
• Nutrition. 2024 Nov 14; 131: 112627112627.

BackgroundThe COntrolling NUTritional Status (CONUT) score and the Global Nutrition Risk Index (GNRI) are screening tools for assessing the risk of malnutrition based on widely available biochemical parameters. The primary objective of this study was to investigate the predictive value of CONUT and GNRI score on 36 months mortality and hospitalization risk in hospitalized older patients.MethodsData of 382 patients (196 women, mean age 80.9±6.8 years) were retrieved from the multicenter Italian Study conducted by the Gruppo Lavoro Italiano Sarcopenia-Trattamento e Nutrizione (GLISTEN) in 12 Acute Care Wards. Sarcopenia was defined as presence of low handgrip strength plus low skeletal mass index (EWGSOP2 criteria). CONUT score was calculated based on serum albumin, total cholesterol and total lymphocyte count, whilst the GNRI was calculated using serum albumin and present body weight/ideal body weight ratio.ResultsDuring the 36-month follow-up, 120 out of 382 participants died (31.4%). From the results of the survival analysis, and after adjustment for potential confounders, participants with CONUT-derived moderate to high risk of malnutrition had shorter survival (HR = 2.67, 95%CI 1.34-5.33 and HR = 3.98, 95% CI: 1.77-8.97, respectively), as well as shorter survival free of urgent hospitalization (HR = 1.91; 95% CI: 1.03-3.55 and HR = 1.98; 95% CI: 1.14-3.42, respectively). Conversely, only GNRI indicative of high risk of malnutrition was an independent predictor of mortality 1.96 (95% CI: 1.06-3.62), but not of hospitalization.ConclusionThe CONUT score seems a valid tool to predict long-term mortality and hospitalization risk. Conversely, the GNRI is associated with long-term mortality, but not with hospital readmissions.Copyright © 2024 Elsevier Inc. All rights reserved.

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