• Nutrition · Nov 2024

    Modulation of Δ5- and Δ6-desaturases in the brain-liver axis.

    • Jessica Zúñiga-Hernández, Camila Farias, Alejandra Espinosa, Lorena Mercado, Alexies Dagnino-Subiabre, CampoAndrea DelADLaboratorio de Fisiología y Bioenergética Celular, Escuela de Química y Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile., Paola Illesca, Luis A Videla, and Rodrigo Valenzuela.
    • Biomedical Sciences Department, Faculty of Health Sciences, University of Talca, Talca, Chile.
    • Nutrition. 2024 Nov 12; 131: 112629112629.

    ObjectiveObesity is associated with liver depletion of ω-3 polyunsaturated fatty acids (ω-3 PUFAS) promoting steatosis and inflammation, whose levels are maintained by diet or biosynthesis involving Δ-5D, Δ-6D desaturases and elongases.MethodWe aimed to assess Δ-5D and Δ-6D activities in liver and brain from mice fed a control diet (CD) or high-fat diet (HFD) for four to sixteen weeks.ResultsHFD led to (1) an early (4 weeks) enhancement in liver Δ-5D, Δ-6D, and PPAR-α activities, without changes in oxidative stress, liver damage or fat accumulation; (2) a latter progressive loss in hepatic desaturation with insufficient compensatory increases in mRNA and protein expression, leading to ω-3 PUFA depletion, PPAR-α down-regulation reducing FA oxidation, and liver steatosis with enhancement in lipogenesis; and (3) brain ω-3 PUFA depletion after 12 to 16 weeks of HFD feeding.ConclusionIn conclusion, the brain-liver axis is drastically affected by obesity in a time dependent fashion.Copyright © 2024 Elsevier Inc. All rights reserved.

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