• Xuejin Cao, Zan Wang, Hongxing Wang, Hengrui Zhou, Jia Quan, Xiaohui Chen, Xi Yang, Shenghong Ju, Yuancheng Wang, and Yijing Guo.
• School of Acupuncture-Moxibustion and Tuina, School of Health Preservation and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing, China.
• Neuroscience. 2025 Jan 26; 565: 420430420-430.

ObjectiveThis study explored structural and functional alterations in the whole brain of stroke patients with hemiplegia.MethodsWe collected multimodal magnetic resonance images of 24 patients with ischaemic stroke and 16 age-matched controls. Resting-state functional connectivity (FC) for all brain regions was evaluated. Diffusion tensor imaging was used to construct white matter structural networks, and the graph properties of the structural network were analysed using graph theory to determine group differences.ResultsThe ipsilesional posterior parietal cortex (PPC) in the frontoparietal network accounts for more than half of the 25 brain regions with altered FC in stroke patients. The nodal efficiency of multiple ipsilesional frontal lobes and cerebellar regions, such as the ipsilateral cerebellum 8, was reduced. The contralesional cerebellum 8 showed elevated FC with the lingual gyrus and the visual network.ConclusionsOur results suggest that the PPC and cerebellum 8 are regions worthy of in-depth study. The cerebellum 8 may supplement deficits in motor balance function by enhancing functional congruence with the visual area.SignificanceThis study identified key brain regions and characteristics that exhibit structural and functional changes following stroke injury.Copyright © 2024 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights reserved.

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