• Meijun Zhang, Si Liu, Xiaoyun Xiong, Mengdie Liu, Ying Wang, Ying Yang, and Qin Xiang.
• Department of Nursing, The Second Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
• Medicine (Baltimore). 2024 Dec 6; 103 (49): e40812e40812.

BackgroundThe significance of virtual reality (VR) technology as an alternative or complementary modality to traditional cardiac rehabilitation is of increasing interest. Numerous studies have examined the effects of virtual reality technology in cardiac rehabilitation patients, but the results have been inconsistent.MethodsWe conducted a systematic search of the Cochrane Library, Web of Science, PubMed, Embase, Scopus, ProQuest, OVID, CINAHL, SinoMed, CNKI, WanFang, VIP Database, and ReadShow databases following the Program for Systematic Review and Meta-Analysis guidelines. The search included studies published up until June 30, 2024. The Cochrane Risk of Bias Tool was used to examine the methodological quality of the included randomized controlled studies. When feasible, a meta-analysis was performed to calculate the pooled effects using Review Manager (version 5.3). Otherwise, narrative summaries were performed.ResultsA total of 11 studies with 1093 patients were included. The results of systematic review and meta-analysis showed that virtual reality technology improved patients' exercise capacity (mean difference: 53.26, 95% confidence interval [CI]: 45.14-61.37; P < .00001); anxiety (standardized mean difference [SMD]: -0.39, 95% CI: -0.69, -0.08, P = .01); depression (SMD: -0.48, 95% CI: -0.79, -0.17; P = .003); stress (SMD: -0.72, 95% CI: -1.03, -0.40; P < .00001); emotional tension (SMD: -0.81, 95% CI: -1.15, -0.47; P < .00001); emotional tension (SMD: -0.64, 95% CI: -0.98, -0.30; P = .0002), and intrapsychic stress (SMD: -0.56, 95% CI: -0.90, -0.23; P = .0009).ConclusionVirtual reality-based interventions can be effective in improving patients' exercise capacity and negative emotions. However, further research is needed to determine the efficacy of VR for other clinical outcomes.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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