• Linping Du, Yuqun Wang, Honglei Ma, Jiaheng Fan, Shiqi Wang, Junhong Liu, and Xiaodong Wang.
• Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Weifang, China.
• Medicine (Baltimore). 2024 Dec 13; 103 (50): e40773e40773.

AbstractSystemic lupus erythematosus (SLE) is an autoimmune condition that is characterized by the production of autoantibodies and sustained inflammatory damage. Coronary heart disease (CHD) is a common complication of SLE, significantly increases CHD-related mortality in SLE patients. Despite conventional risk factors, the mechanisms contributing to a higher CHD risk require further investigation, with the immune and inflammatory aspects of SLE playing a significant role. Endothelial cell damage and dysfunction are key factors in the progression of coronary atherosclerosis in SLE patients. This review specifically focuses on endothelial dysfunction and the role of specific microRNAs in the context of SLE and CHD. In addition, we discuss the effects and functions of oxidative stress markers, endothelial progenitor cells, and circulating endothelial cells in individuals with both SLE and CHD. We also explored the typical inflammatory markers associated with SLE and CHD, addressing their clinical significance and limitations.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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