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J Pain Palliat Care Pharmacother · Dec 2024
Intravenous Magnesium Sulfate as an Adjunct to Intravenous Ketamine for Acute Pain: A Case Series.
- Nathan Smith, Sanny Juresic, Kia Lor, Carrie Schmidt, Annie Bell Howrigon, and Oludare Olatoye.
- Mayo Clinic Department of Pharmacy.
- J Pain Palliat Care Pharmacother. 2024 Dec 13: 181-8.
AbstractIntravenous (IV) magnesium sulfate, a versatile electrolyte, plays a pivotal role across various medical domains. From cardiac care to obstetrics, gastrointestinal to pulmonary therapies, the impact is far-reaching among acute care services. Notably, in the postoperative phase of care, it shares intriguing similarities with ketamine as an NMDA receptor antagonist. This case series describes the difficulties experienced with postoperative analgesia in three patient cases with complex comorbidities and discusses the beneficial impact observed when magnesium was administered concomitantly with ketamine. Further research is necessary to outline the specific role, ideal population, and recommended bolus and infusion rate for optimal analgesic efficacy.
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