• Yan Li, Yingnan Nie, Xiao Li, Xi Cheng, Guanyu Zhu, Jianguo Zhang, Zhaoyu Quan, and Shouyan Wang.
• Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China; Ministry of Education Frontiers Center for Brain Science, Fudan University, Shanghai, China.
• Neuromodulation. 2024 Dec 14.

ObjectiveThis study aims to facilitate the translation of innovative closed-loop deep brain stimulation (DBS) strategies from theory to practice by establishing a research platform. The platform addresses the challenges of real-time stimulation artifact removal, low-latency feedback stimulation, and rapid translation from animal to clinical experiments.Materials And MethodsThe platform comprises hardware for neural sensing and stimulation, a closed-loop software framework for real-time data streaming and computation, and an algorithm library for implementing closed-loop DBS strategies. The platform integrates hardware for both animal and clinical research. The closed-loop software framework handles the entire closed-loop stimulation, including data streaming, stimulation artifact removal, preprocessing, a closed-loop stimulation strategy, and stimulation control. It provides a unified programming interface for both C/C++ and Python, enabling secondary development to integrate new closed-loop stimulation strategies. Additionally, the platform includes an algorithm library with signal processing and machine learning methods to facilitate the development of new closed-loop DBS strategies.ResultsThe platform can achieve low-latency feedback stimulation control with response times of 6.23 ± 0.85 ms and 6.95 ± 1.11 ms for animal and clinical experiments, respectively. It effectively removed stimulation artifacts and demonstrated flexibility in implementing new closed-loop DBS algorithms. The platform has integrated several typical closed-loop protocols, including threshold-adaptive DBS, amplitude-modulation DBS, dual-threshold DBS and neural state-dependent DBS.ConclusionsThis work provides a research tool for rapidly deploying innovative closed-loop strategies for translational research in both animal and clinical studies. The platform's capabilities in real-time data processing and low-latency control represent a significant advancement in translational DBS research, with potential implications for the development of more effective therapeutic interventions.Copyright © 2024 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.

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