• Sumira Kiran, Shuja Ikram, Ahtesham Khizar, Muhammad Kaleem Iftikhar, Haseeb Mehmood Qadri, Muhammad Waqas Umer, Khawar Anwar, and Asif Bashir.
• Sumira Kiran, MBBS, MS Assistant Professor Neurosurgery, Department of Neurosurgery Unit-I, Punjab Institute of Neurosciences, Lahore, Pakistan.
• Pak J Med Sci. 2024 Dec 1; 40 (12PINS Suppl): S20S24S20-S24.

ObjectivesTo determine the incidence of postoperative cerebrospinal fluid (CSF) leaks after endoscopic endonasal transsphenoidal surgery (EETS) for pituitary adenomas without sellar floor reconstruction (SFR).MethodsThis retrospective observational study was conducted at Department of Neurosurgery, Punjab Institute of Neurosciences (PINS), Lahore, Pakistan from January, 2018 to December, 2022. It is a non-probability based consecutive case series. A total of 316 patients meeting the inclusion criteria were selected.ResultsAmong the 316 patients, 102 (32.3%) were male, while 214 (67.7%) were female. Mean age was 40.98 ± 7.8 SD (range 23 to 65 years). Regarding size of pituitary adenomas, 19 (6%) were microadenomas and 297 (94%) were macroadenomas. Overall postoperative CSF (poCSF) leak in our patients was 2.8%. Among cases with poCSF leak, 4 (3.9%) were male and five were female (2.3%) with the P-value of 0.477. Regarding size of pituitary adenomas, only one (5.3%) microadenoma had poCSF leak whereas 8 (2.7%) macroadenomas had poCSF leak with the P-value of 0.432.ConclusionPituitary adenomas can be successfully treated with EETS without SFR in patients who do not experience intraoperative CSF leak.Copyright: © Pakistan Journal of Medical Sciences.

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