• G L Nielsen, K L Faarvang, B S Thomsen, K L Teglbjaerg, L T Jensen, T M Hansen, H H Lervang, E B Schmidt, J Dyerberg, and E Ernst.
• Department of Rheumatology, Aalborg Hospital, Copenhagen, Denmark.
• Eur. J. Clin. Invest. 1992 Oct 1; 22 (10): 687691687-91.

Study ObjectiveTo determine the effect of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) on disease variables in patients with rheumatoid arthritis.DesignMulticenter, randomized, placebo controlled, double blind.SettingThree Danish hospital Departments of Rheumatology.PatientsFifty-one patients with active rheumatoid arthritis.InterventionRandom allocation to 12 weeks of treatment with either six n-3 PUFA capsules (3.6 g) or six capsules with fat composition as the average Danish diet.Main ResultsSignificant improvement of morning stiffness and joint tenderness. No significant effect on the four other assessed clinical parameters. No serious side effects.ConclusionsDietary supplementation with n-3 PUFA in patients with rheumatoid arthritis improved two out of six patient reported disease parameters. Further studies are needed to clarify the more precise role of n-3 PUFA in the treatment of rheumatoid arthritis.

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