• Miaomiao Liu, Jing Wang, Rui Wang, Fengjiao Sun, Mengdi Wang, Yuwei Liu, He Gong, Kai Qi, Minglong Li, Quanyuan Liu, and Hongcai Wang.
• School of Medical Imaging, Binzhou Medical University, 264000 Yantai, PR China; Department of Radiology, Binzhou Medical University Hospital, Binzhou, PR China.
• Neuroscience. 2025 Jan 4.

AbstractAstragaloside Ⅳ (AS-Ⅳ) improved the motor behavior of PD mouse but the alteration of imaging in the PD mice brain was unclear. PD models were established by unilateral injection of ROT into the substantia nigra pars compacta (SNc) of mice. AS-Ⅳ (4 mg/kg) was intraperitoneally injected once a day for 14 days. The pole test and rotarod test were performed to evaluate the alteration of behavior at 32 weeks. The flow cytometry, electrophysiological recordings and MRI were used to assess the neuroprotective effects of AS-IV. AS-Ⅳ ameliorated the motor deficits and reduced the incidence of dystonia in PD animal models. AS-Ⅳ administration inhibited the activation of CD4+ T cells and increased the percentage of dopaminergic neurons of burst firing. Meanwhile, AS-Ⅳ altered the brain tissue microstructure and T2 values in SN. AS-Ⅳ improved motor impairments and efficiently performed a neuroprotective function in ROT-induced mouse model.Copyright © 2024 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights reserved.

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