• Junyu Wu, Gengxin Lu, Zhihui Zheng, Zhezhi Deng, Junjie Guo, Minping Li, Dongxiao Zhou, Weiwei Qi, Shifeng Zhang, Yuemin Qiu, Xintian Li, Xiaoqiu Liang, Xue Xu, and Haiwei Huang.
• Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, No.58 Zhongshan Road 2, Guangzhou 510080, China. Electronic address: wujy299@mail2.sysu.edu.cn.
• Neuroscience. 2025 Feb 16; 567: 182194182-194.

AbstractAcute peripheral vestibular dysfunction is associated with a variety of postural and balance disturbances. Vestibular rehabilitation training (VRT) is widely acknowledged as an effective intervention for promoting vestibular compensation. Nevertheless, the broader implementation of early VRT is hindered by an incomplete understanding of its neurobiological mechanisms. Building upon prior research, the present study investigates the effects of early VRT on postural behavior and the cellular mechanisms within the medial vestibular nucleus (MVN) following unilateral vestibular neurectomy (UVN) in a murine model. Through the use of progressive motorized running wheel training, we assessed vestibular syndrome, motor function behaviors, and plasticity events, including cell proliferation and gliogenesis within the MVN. Our findings suggest that VRT facilitates the recovery of postural motor deficits during vestibular compensation, likely mediated by cell proliferation and glial responses, particularly the proliferation of microglia, in the MVN. Furthermore, we demonstrate that ultra-early rehabilitation training yields greater benefits for the long-term recovery of dynamic deficits following UVN. These results carry significant implications for the clinical implementation of early VRT in patients experiencing acute peripheral vestibular dysfunction.Copyright © 2025. Published by Elsevier Inc.

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