• Amelia L Muhs, Kevin P Seitz, Edward T Qian, Brant Imhoff, Li Wang, Matthew E Prekker, Brian E Driver, Stacy A Trent, Daniel Resnick-Ault, Steven G Schauer, Adit A Ginde, Derek W Russell, Sheetal Gandotra, David B Page, John P Gaillard, Lane M Smith, Andrew J Latimer, Steven H Mitchell, Nicholas J Johnson, Shekhar A Ghamande, Heath D White, Kevin W Gibbs, Jessica A Palakshappa, Derek J Vonderhaar, David R Janz, Micah R Whitson, Christopher R Barnes, Alon Dagan, Ari Moskowitz, Vijay Krishnamoorthy, James T Herbert, Michael D April, Aaron M Joffe, Jeremy P Walco, Christopher G Hughes, Jonathan K Shipley, Amelia W Maiga, Bradley D Lloyd, Stephanie C DeMasi, Wesley H Self, Todd W Rice, Matthew W Semler, Jonathan D Casey, and Pragmatic Critical Care Research Group.
• Division of Pulmonary & Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States. Electronic address: amelia.muhs@vumc.org.
• Chest. 2025 Jan 11.

BackgroundAirway management is a critical component of the care of patients experiencing cardiac arrest, but data from randomized trials on the use of video vs direct laryngoscopy for intubation in the setting of cardiac arrest are limited. Current AHA guidelines recommend placement of an endotracheal tube either during CPR or shortly after return of spontaneous circulation but do not provide guidance around intubation methods, including the choice of laryngoscope.Research QuestionDoes use of video laryngoscopy improve the incidence of successful intubation on the first attempt, compared to use of direct laryngoscopy, among adults undergoing tracheal intubation after experiencing cardiac arrest?Study Design And MethodsThis secondary analysis of the Direct versus Video Laryngoscope (DEVICE) trial compared video laryngoscopy versus direct laryngoscopy in the subgroup of patients who were intubated following cardiac arrest. The primary outcome was the incidence of successful intubation on the first attempt. Additional outcomes included the duration of laryngoscopy.ResultsAmong the 1,417 patients in the DEVICE trial, 113 (7.9%) had experienced cardiac arrest prior to intubation, of whom 48 were randomized to the video laryngoscopy group and 65 to the direct laryngoscopy group. Successful intubation on the first attempt occurred in 40 of 48 patients (83.3%) in the video laryngoscopy group and 42 of 65 patients (64.6%) in the direct laryngoscopy group (absolute risk difference, 18.7 percentage points; 95% confidence interval [CI], 1.2 to 36.2; P = 0.03). The mean duration of laryngoscopy was 48.0 seconds (standard deviation [SD], 37.3 seconds) in the video laryngoscope group and 98.0 seconds (SD, 122.4) in the direct laryngoscopy group (mean difference, -50.0; 95% CI, -86.8 to -13.3, P = 0.004).InterpretationAmong adults undergoing tracheal intubation after experiencing cardiac arrest, use of video laryngoscopy was associated with increased incidence of successful intubation on the first attempt and shortened duration of laryngoscopy, compared to use of direct laryngoscopy.Copyright © 2025. Published by Elsevier Inc.

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