• Yiran Gu, Timothy A Matthews, and Jian Li.
• Department of Environmental Health Sciences, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
• Prev Med. 2025 Jan 11; 191: 108225108225.

AimsCardiovascular disease (CVD) is the leading cause of death in the United States (U.S.). This study aimed to explore prospective associations between long working hours with CVD mortality using a large, national study in the U.S.MethodsData from the Midlife in the U.S. (MIDUS) Study were used, including 4051 currently employed participants without prior experience of myocardial infarction or stroke at baseline in 1995-1996. Working hours were categorized into: <35 h/week, 35-40 h/week (reference), 41-48 h/week, 49-54 h/week, and ≥ 55 h/week. Mortality data were extracted from the National Death Index (NDI) through Spring 2021. Cox proportional hazards regression was applied to analyze the prospective associations between working hours at baseline and CVD mortality, adjusting for sociodemographic and lifestyle factors. Stratified analyses by socioeconomic status (i.e., education and financial situation) were also conducted.ResultsLong working hours (≥55 h/week) were significantly associated with increased CVD mortality (adjusted HR 1.50; 95 % CI 1.03-2.17) compared to the reference group. Subgroup analyses showed that individuals with low education level or poor financial situation had a higher risk of CVD mortality when working long hours.ConclusionLong working hours are a significant risk factor for CVD mortality in this national sample of U.S. workers, and participants with low socioeconomic status are more vulnerable to the effects of long working hours on CVD deaths. These findings highlight the need for considering working hour interventions in public health strategies to improve cardiovascular health outcomes in the workforce.Copyright © 2025 Elsevier Inc. All rights reserved.

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