• Michael Chia-Yen Chou, Hsiang-Wen Chien, Chia-Yi Lee, Shun-Fa Yang, and Hung-Yu Lin.
• Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
• Int J Med Sci. 2025 Jan 1; 22 (3): 551557551-557.

AbstractDiabetic retinopathy (DR) is a microvascular complication of diabetes characterized by an inflammatory response. The H19 gene plays a role in regulating inflammation and is associated with chronic systemic inflammation. This study aims to investigate the potential correlation between single-nucleotide polymorphisms (SNPs) in the H19 gene and the development of DR. Five loci of H19 SNPs-rs3024270 (C/G), rs2839698 (C/T), rs3741219 (A/G), rs2107425 (C/T), and rs217727 (C/T)-were genotyped using TaqMan allelic discrimination in 454 individuals without DR and 272 DR participants. The results indicate that the H19 SNP rs3741219 AG (p = 0.030) and AG+GG (p = 0.037) alleles are significantly associated with an increased risk of developing DR in individuals with diabetes onset before the age of 45. Additionally, diabetic individuals with the H19 SNP rs3741219 AG+GG genotype also showed significantly higher serum creatinine (p = 0.034), lower glomerular filtration rate (GFR) (p = 0.013), higher total cholesterol/HDL ratio (p = 0.031), and higher triglycerides (p = 0.012). In an age-based subgroup analysis, GFR was significantly lower in diabetic patients with an onset of diabetes before 45 years and with the H19 SNP rs3741219 AG+GG genotype (p = 0.012). In conclusion, the presence of the H19 SNP rs3741219 variant is associated with a higher risk of DR in individuals with early-onset diabetes, and the relationship between the rs3741219 variant and decreased GFR is particularly pronounced in this population.© The author(s).

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