• Neuroscience · Feb 2025

    Multidimensional-based exploration of gut microbial and metabolite differences in patients with recurrent stroke.

    • Zongwei Fang, Sijie Chang, Peiguang Niu, Chunhua Wang, and Jinhua Zhang.
    • Department of Pharmacy Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics Fujian Medical University Fuzhou China.
    • Neuroscience. 2025 Feb 4.

    ObjectivesThe purpose of this study was to examine variations in gut microbes and their metabolites between patients with original and recurrent stroke, providing insights and justification for the diagnosis and prevention of ischemic stroke progression from the perspective of the gut microbiota-metabolite-brain axis.MethodsIn this study, fecal samples were collected from 95 patients with Original stroke (Os) and 39 patients with Recurrent stroke (Rs) to assess differences in gut microbiota between two groups. Then LC-MS non-targeted metabolomics was used to screen out the different metabolites and to reveal the physiological changes related to the progression of ischemic stroke.ResultsBeta diversity analysis revealed significant differences in community composition between two groups. Compared with Os patients, 26 genera were dysregulated in Rs patients. For example, Prevotella, Lachnospiraceae_UCG-010, Holdemanella, and Coprococcus were significantly depleted in the Rs group. Correlation analysis showed that the risk of stroke recurrence was negatively correlated with Lachnospiraceae_UCG-010. A total of 38 differential metabolites were identified in both groups. In Rs group, 8 metabolites were up-regulated, including carbohydrates and terpene lactones, and 30 metabolites were down-regulated, including sesquiterpenes, triterpenes, and fatty acids and their couplings. These metabolites are significantly enriched in the pathways of arachidonic acid metabolism, betaine biosynthesis, and linoleic acid metabolism.ConclusionsCompared with the Os, Rs was mainly characterized by severe destruction of anaerobic bacteria and significant depletion of SCFAs-producing bacteria. In addition, the related compounds involved in arachidonic acid metabolism and linoleic acid metabolism pathway may be biomarkers related to ischemic stroke progression.Copyright © 2025 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights reserved.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…