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Eur. J. Clin. Invest. · Feb 2025
Effects of glucagon-like PEPTIDE-1 receptor agonists on incidence of hepatocellular carcinoma and liver decompensation in patients with diabetes: A systematic review and META-analysis.
- Andrea Pasta, Antonio Facciorusso, Maria Corina Plaz Torres, Edoardo G Giannini, and Rodolfo Sacco.
- Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy.
- Eur. J. Clin. Invest. 2025 Feb 12: e70000e70000.
AbstractThis systematic review and meta-analysis evaluated the impact of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on hepatocellular carcinoma (HCC) and liver decompensation in patients with type 2 diabetes. Analysing over 641,377 patients, GLP-1RA use was associated with a significant 58% reduction in HCC risk, particularly in patients with cirrhotis. While a trend towards reduced liver decompensation risk was observed, it was not statistically significant. These findings suggest a potential role for GLP-1RAs in HCC risk stratification and prevention strategies.© 2025 The Author(s). European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.
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