• Yong Chen, Shuang Liu, Wei Guo, and Zeng-zhi Wang.
• Beijing An-zhen Hospital, Beijing 100029, China.
• Zhonghua Jie He He Hu Xi Za Zhi. 2013 Jul 1;36(7):516-21.

ObjectiveTo explore the clinical value of heart-type fatty acid binding protein (H-FABP) for the assessment of the short-term prognosis in acute pulmonary embolism (APE) patients with hemodynamic stability on admission.MethodA total of 156 APE patients with hemodynamic stability on admission were hospitalized in Beijing Anzhen hospital from December 2009 to December 2010, and the final study population comprised 90 patients [37 men and 53 women; age (61.1 ± 14.6) years], who were taken blood samples before thrombolysis or anticoagulation for plasma H-FABP level measurement by a solid-phase enzyme-linked immunoabsorbent assay based on the sandwich principle, cardiac troponin I (cTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP) by heterogeneous immunoassay. All had 30-day follow-up and divided them into the complicated clinical course group (n = 7) and the simple clinical course group (n = 83). The clinical and follow-up data was analyzed by Mann-Whitney U test, Pearson Chi-Square test, Continuity Correction test and logistic regression.ResultsThe level of H-FABP was higher in the complicated clinical course group than it in the simple clinical course group (U = 54.000, P < 0.01). With ROC analysis, 7 µg/L was identified as the best cutoff value of H-FABP in this study, and the differences of AUC among H-FABP, cTnI and NT-proBNP were no statistical significance. By univariable logistic regression, H-FABP ≥ 6 µg/L, heart rate ≥ 106 beats/min and syncope ( all P < 0.01) may predict the short-term prognosis in APE patients with hemodynamic stability. H-FABP ≥ 6 µg/L and syncope (both P < 0.05) may also be 30-day predictor by multivariable logistic regression. NT-proBNP or cTnI combined with H-FABP may increase 30-day prognosis value in APE patients with hemodynamic stability.ConclusionsH-FABP, alone or in combination with other clinical data may predict 30-day prognosis in APE patients with hemodynamic stability on admission. H-FABP is superior to cTnI and NT-proBNP in the predication of 30-day prognosis in APE patients with hemodynamic stability on admission.

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