• Crit Care · Jan 2013

    Editorial Comment

    The gut-brain axis in the critically ill: Is glucagon-like peptide-1 protective in neurocritical care?

    • Mark P Plummer, Juris J Meier, and Adam M Deane.
    • Crit Care. 2013 Jan 1;17(4):163.

    AbstractEnteral nutrient is a potent glucagon-like peptide-1 (GLP-1) secretagogue. In vitro and animal studies indicate that GLP-1 has immune-modulatory and neuroprotective effects. To determine whether these immune-modulatory and neuroprotective effects of GLP-1 are beneficial in the critically ill, studies achieving pharmacological GLP-1 concentrations are warranted.

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