• Rev Med Chir Soc Med Nat Iasi · Apr 2011

    [Sensitization to ascaris lumbricoides and asthma severity in children].

    • Carmen Rîpă, Roxana-Gabriela Bahnea, Ingrid Cojocaru, Mihaela Cătălina Luca, Maria Leon, and Mariana Luca.
    • Universităţii de Medicină şi Farmacie Gr. T. Popa Iaşi, Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi, Facultatea de Medicină.
    • Rev Med Chir Soc Med Nat Iasi. 2011 Apr 1;115(2):387-91.

    UnlabelledThere is little information concerning asthma severity and sensitization to Ascaris lumbricoides in pediatric patients.Material And MethodsThe relationship between sensitization to Ascaris lumbricoides and asthma severity in 219 patients with a high prevalence of parasitic exposure (IgE antibodies) was studied by using linear, multivariate and logistic regression.ResultsSensitization to Ascaris lumbricoides was associated with positive skin tests for aeroallergens, increased total serum IgE, increased eosinophils, reductions in FEV1 and FEV1/FVC ratio, increased airway Methacholine, bronchodilator responsiveness, and hospitalizations for asthma in the past year.ConclusionsSensitization to Ascaris lumbricoides is associated with increased severity of asthma among Romanian children. This association is mediated by a high degree of atopy among the asthma children sensitized to Ascaris lumbricoides and belonging to a population with a low prevalence of helminthiasis.

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