• J Perinatol · Jan 2010

    Maternal consumption of polyphenol-rich foods in late pregnancy and fetal ductus arteriosus flow dynamics.

    • P Zielinsky, A L Piccoli, J L Manica, L H Nicoloso, H Menezes, A Busato, M R Moraes, J Silva, L Bender, P Pizzato, L Aita, M Alievi, I Vian, and L Almeida.
    • Fetal Cardiology Unit, Institute of Cardiology of Rio Grande do Sul/FUC, Porto Alegre, Brazil. zielinsky@cardiol.br
    • J Perinatol. 2010 Jan 1;30(1):17-21.

    ObjectiveTo test the hypothesis that maternal consumption of polyphenol-rich foods during third trimester interferes with fetal ductal dynamics by inhibition of prostaglandin synthesis.Study DesignIn a prospective analysis, Doppler ductal velocities and right-to-left ventricular dimensions ratio of 102 fetuses exposed to polyphenol-rich foods (daily estimated maternal consumption >75th percentile, or 1089 mg) were compared with 41 unexposed fetuses (flavonoid ingestion <25th percentile, or 127 mg).ResultIn the exposed fetuses, ductal velocities were higher (systolic: 0.96+/-0.23 m/s; diastolic: 0.17+/-0.05 m/s) and right-to-left ventricular ratio was higher (1.23+/-0.23) than in unexposed fetuses (systolic: 0.61+/-0.18 m/s, P<0.001; diastolic: 0.11+/-0.04 m/s, P=0.011; right-to-left ventricular ratio: 0.94+/-0.14, P<0.001).ConclusionAs maternal polyphenol-rich foods intake in late gestation may trigger alterations in fetal ductal dynamics, changes in perinatal dietary orientation are warranted.

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