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- Wudayagiri Rajendra, Arunmozhiarasi Armugam, and Kandiah Jeyaseelan.
- Department of Biochemistry, Faculty of Medicine, National University of Singapore, 8, Medical Drive, Singapore, Singapore 117597.
- Toxicon. 2004 Jul 1;44(1):1-17.
AbstractThe use of toxins as novel molecular probes to study the structure-function relationship of ion-channels and receptors as well as potential therapeutics in the treatment of wide variety of diseases is well documented. The high specificity and selectivity of these toxins have attracted a great deal of interest as candidates for drug development. This review highlights the involvement of the proteins and peptide toxins as well as non-proteinaceous compounds derived from both venomous and non-venomous animals, in anti-nociception and anti-inflammation. The possible mechanisms of these potential therapeutic agents and possible clinical applications in the treatment of pain and inflammation are also summarized.
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