• Imad T Awad, Deirde Murphy, Damian Stack, Brian J Swanton, Rodney I Meeke, and George D Shorten.
• Department of Anesthesia and Intensive Care Medicine, Cork University Hospital, Cork, Republic of Ireland.
• J Clin Anesth. 2002 Nov 1;14(7):481-5.

Study ObjectivesTo compare the prophylactic antiemetic efficacy of the combination of ondansetron and droperidol with that of droperidol alone in patients undergoing elective laparoscopic cholecystectomy.DesignRandomized, double-blind controlled trial. University affiliated teaching hospital after induction of standardized general anesthesia.Patients64 ASA physical status I or II patients aged 18 to 80 years, undergoing elective laparoscopic cholecystectomy.InterventionFollowing induction of general anesthesia, patients received either droperidol 1.25 mg intravenously (IV; n = 30; Group D) or the combination of droperidol 1.25 mg IV and ondansetron 4 mg IV (n = 34; Group D+O).MeasurementsNumber and severity of nausea episodes, number of emetic episodes, total analgesic consumption, and rescue antiemetic administration were assessed at 1, 3, and 24 hours after admission to the recovery room. Data were analyzed using Fisher's Exact test and unpaired Student's t-test; a p-value <0.05 was considered significant.ResultsThe proportions of patients who experienced nausea (70% and 53% for D and D+O groups, respectively) and vomiting (30% and 19% for D and D+O groups, respectively) were similar in the two groups. The frequency of moderate and severe nausea (requiring administration of antiemetic) was less in group D + O (7%) compared with group D (19%; p < 0.05).ConclusionsPatients who received the combination of droperidol and ondansetron experienced less severe nausea compared with patients who received droperidol alone.Copyright 2002 by Elsevier Science Inc.

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