• J Clin Anesth · Aug 2000

    Randomized Controlled Trial Clinical Trial

    Sevoflurane-N2O versus propofol/isoflurane-N2O during elective surgery using the laryngeal mask airway in adults.

    • C E Smith, J S Lever, S Sawkar, A C Pinchak, and J F Hagen.
    • Department of Anesthesiology, MetroHealth Medical Center, Faculty of Medicine, Case Western Reserve University, Cleveland, OH 44109, USA. csmith@metrohealth.org
    • J Clin Anesth. 2000 Aug 1;12(5):392-6.

    Study ObjectivesTo compare a sevoflurane-nitrous oxide (N2O) general anesthetic technique with a standard technique of propofol for induction, and isoflurane-N2O for maintenance.DesignProspective, randomized study.SettingUniversity-affiliated tertiary-care hospital.Patients62 adults undergoing elective surgery using the laryngeal mask airway (LMA).InterventionsPatients received either the standard technique of propofol for induction and isoflurane-N2O for maintenance (controls) or sevoflurane-N2O for both induction and maintenance of general anesthesia.MeasurementsInduction and emergence times, heart rate, blood pressure, oxygen saturation, and end-tidal carbon dioxide were recorded.Main ResultsTime to loss of consciousness was faster after propofol (mean +/- SEM: 51 +/- 3 sec) than after sevoflurane-N2O (85 +/- 10 sec; p < 0.05). Ready for surgery times, were however, similar between groups (10 +/- 1 vs. 11 +/- 1 min, respectively). All patients in the control group had apnea after LMA insertion compared with 4 patients in the sevoflurane-N2O group (p < 0.05). Heart rate was lower 5 and 10 minutes after LMA insertion in the sevoflurane-N2O group (69 +/- 3 and 66 +/- 3 bpm) versus the control group (81 +/- 3 bpm and 74 +/- 3 bpm, p < 0.05). After cessation of anesthetic gases, there were no differences in time to LMA removal, eye opening, or exiting the operating room (OR) between the control group (7, 8, and 10 min) and sevoflurane-N2O groups (7, 8, and 12 min, respectively). The majority of patients in both groups (92% to 97%) rated their anesthetic experience as excellent or good.ConclusionsSevoflurane-N2O and propofol provided comparable conditions for LMA insertion. Sevoflurane-N2O was not associated with a faster return of consciousness or faster time to exit the OR compared with isoflurane-N2O.

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