• Ming H Jih, Paul M Friedman, Neil Sadick, Denise K Marquez, Arash Kimyai-Asadi, and Leonard H Goldberg.
• DermSurgery Associates, Houston, Texas 77030, USA. mjih@dermsurgery.org
• Lasers Surg Med. 2004 Jan 1;34(5):446-50.

Background And ObjectivesAdvancements in laser treatment of leg veins necessitate concurrent investigations in topical anesthesia to minimize treatment-related pain. To evaluate the efficacy of the S-Caine Peel for providing topical anesthesia after a 60-minute application.Study Design/Patients And MethodsA randomized, double-blinded, placebo-controlled trial was performed in two centers. Sixty patients received S-Caine Peel and placebo vehicle on different treatment sites for 60 minutes prior to laser treatment of leg veins using a 1,064 nm long-pulsed Nd:YAG laser. Patients rated their level of pain using a visual analog scale. Adequacy of anesthesia and expressed pain at each site were rated by the investigator.ResultsThe mean visual analog scale (VAS) was 27 mm for active sites compared to 43 mm for placebo (P < 0.001). Improved pain relief was noted for 67% of active versus 30% of placebo sites (P < 0.001). Anesthesia was judged adequate by the investigator for 55% of active compared with 12% of placebo sites (P < 0.001).ConclusionsThe S-Caine Peel is safe and effective when applied for 60 minutes prior to laser therapy of leg veins.Copyright 2004 Wiley-Liss, Inc.

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