• L Barvais, A A D'Hollander, F Cantraine, E Coussaert, and G Diamon.
• Department of Anesthesiology, Erasmus Hospital, Brussels, Belgium.
• J Clin Anesth. 1994 Jul 1;6(4):297-302.

Study ObjectiveTo evaluate the predictive accuracy of midazolam during cardiac anesthesia so as to orient the selection of the most appropriate pharmacokinetic model for use in a computer-assisted continuous-infusion system.DesignRetrospective analysis.SettingOperating room at a university hospital.Patients66 consecutive middle-aged and elderly coronary patients scheduled for coronary artery bypass graft (CABG) surgery.InterventionsPatients were anesthetized using a variable-rate infusion of alfentanil combined with midazolam in an attempt to achieve and maintain target concentrations of 100 ng/ml or 500 ng/ml.Measurements And Main ResultsA total of 323 arterial blood samples were taken, and serum midazolam concentrations were measured by high-performance liquid chromatography. Predicted midazolam concentrations were calculated using 3 selected data sets. Their bias, inaccuracy, and dispersion were assessed by determining the median performance error, the median absolute performance error (MDAPE), and the 10th and 90th percentiles. Two of the selected data sets of midazolam, with a clearance lower than 5 ml/kg/min, were very accurate (MDAPE less than 20%) in predicting low or high prebypass concentrations of midazolam in adult patients with good left ventricular function.ConclusionsTwo of the 3 pharmacokinetic data sets of midazolam studied may be selected when using a computer-assisted infusion system in adult coronary patients.

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