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Biology of the neonate · Jan 1996
Measurement of methemoglobin after EMLA analgesia for newborn circumcision.
- R M Law, S Halpern, R F Martins, H Reich, V Innanen, and A Ohlsson.
- Department of Pharmacy, Women's College Hospital, Toronto, Ont., Canada.
- Biol. Neonate. 1996 Jan 1;70(4):213-7.
AbstractA statistically significant (p = 0.049) increase in methemoglobin (MetHb), which did not exceed normal values, was noted 8 h after application of 1 g of EMLA (Eutectic Mixture of Local Anesthetics) to the foreskin of 10 normal newborns to reduce pain associated with circumcision. The highest MetHb concentration observed was 3 g/l (toxic > 50 g/l). No infant showed clinical signs of methemoglobinemia. We conclude that EMLA is safe to use as a local anesthetic in term neonates.
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